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SEALLAGEN PRODUCTS FOR MEDICAL USE

Collagen is an essential component of cell-matrix adhesion and therefore, an ideal substrate for cell and tissue culture. Our Seallagen (Biomedical Grade Echinoderm Collagen) products are suited for a variety of applications for multiple cell types and regenerative medicine, and offers collagen characteristics such as Type I like, Type II like, and Type V like. ME Bio’s next-generation collagen is an ideal tool to work with due to its unique features (proven by analysis of histological preparation):

  • Non-mammalian, BSE, and disease vector free
  • Non-cytotoxic
  • Cleaner at miRNA levels when compared to mammalian alternatives giving customers a cleaner cell culture with less off-target effects
  • Bioresorbable and biocompatible
  • Increased surface area : media ratio – allows for improved nutrients and waste exchange, lowering the risk of cell necrosis.
  • Translatability – in vitro to in vivo applications
  • Batch-to-batch consistency
  • 2D and 3D cell culture

Benefits

  • Improvement of cell adherence
  • Natural signals for cell growth, migration and differentiation
  • High concentration for flexible use
  • Environment provides natural signal for cells
  • Proven biocompatibility and biodegradability in vivo
  • Long shelf life

Applications

  • Collagen Standard (Type-I like, Type-II like, and Type-V like)
  • Antigen for Antibody Production
  • Coating Material and 2D/3D matrix for Cell Culture
  • Formation of Collagen Gels and Bio inks
  • Fabrication of Biomaterials and Medical Devices

Benefits

  • Improvement of cell adherence
  • Natural signals for cell growth, migration and differentiation
  • High concentration for flexible use
  • Environment provides natural signal for cells
  • Proven biocompatibility and biodegradability in vivo
  • Long shelf life

Applications

  • Collagen Standard (Type-I like, Type-II like, and Type-V like)
  • Antigen for Antibody Production
  • Coating Material and 2D/3D matrix for Cell Culture
  • Formation of Collagen Gels and Bio inks
  • Fabrication of Biomaterials and Medical Devices

Seallagen (Biomedical Grade Echinoderm Collagen) constitutes an ideal standard for collagen purity (> 98% collagen content), functionality, and one of the most native-like collagens available as of today. Our soluble collagen provides in-vivo-like conditions to support the adherence, growth and differentiation of your cells. Seallagen can be applied as a thin coating to any cell culture dish. For use in 3D cell culture, hydrogels can be generated using standard protocols. This flexible matrix may be mixed with other ECM components, antibiotics, or growth factors. Supplemental cross-linking by the customer is also feasible if desired. Seallagen matrix enables growth and differentiation of multiple cell types, representing an excellent scaffold for adherent cells and complex tissues in a broad variety of clinical applications, such as membranes for medical devices, dental membranes, cell therapy/ATMPs or implants.

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